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Theme
Organizations
Description of project
Years
Number of records or individuals for the cohort
Main investigator(s)
Project coordination
Project numbers
Publications
Cancer – Breast – National Breast Screening Study – NBSS – Lifestyle – Diet – Smoking – Obesity
Department of Preventive Medicine and Biostatistics (now Department of Public Health Sciences), University of Toronto
The Canadian National Breast Screening Study (NBSS) was a randomized clinical trial which began in 1980, to determine the efficacy of screening for women aged 40 to 49 and 50 to 59. Women were recruited in 15 centres across Canada and randomly assigned to study or control groups (see National Breast Screening mortality and cancer incidence study).
About 60% of the women who were enrolled in the clinical trial also completed a self-administered lifestyle and dietary questionnaire. These data were used to study the relationship between dietary intake and a variety of cancers. A number of related papers have been prepared of pooled analyses of various cohorts (including the NBSS) in relation to diet and cancer.
Death years:
1981
– 1988a
1981
– 1993b
1981
– 1999c
Cancer years:
1969
– 1993b
1969
– 1999 (1998 for Quebec )c
89,835 women,a,b,c aged 40–59, on entry to the study
Dr. Tom Rohanc and Dr. A.B. Miller,a,b,c University of Toronto
Elizabeth Coppocka and Maureen Carpenter,b,c Occupational and Environmental Health Research Section, Health Statistics Division, Statistics Canada
1989-025;a 1995-019;b 2000-011c
Rohan TE, Hartwick W, Miller AB, Kandel RA. Immunohistochemical detection of c-erb B-2 and p53 in benign breast disease and breast cancer risk. Journal of the National Cancer Institute 1998; 90(17): 1262-1269.
Rohan TE, Miller AB. A cohort study of cigarette smoking and risk of fibroadenoma. Journal of Epidemiology and Biostatistics 1999; 4(4): 297-302.
Rohan TE, Jain M, Howe GR, Miller AB. A cohort study of dietary carotenoids and lung cancer risk in women. Cancer Causes and Control 2002; 13(3): 231-237.
Terry P, Jain M, Miller AB, Howe GR, Rohan TE. Dietary carotenoid intake and colorectal cancer risk. Nutrition and Cancer 2002; 42(2); 167-172.
Terry PD, Miller AB, Rohan TE. Prospective study of cigarette smoking and colorectal cancer risk in women. International Journal of Cancer 2002; 99(3): 480-483.
Terry PD, Miller AB, Rohan TE. Cigarette smoking and breast cancer risk: a long latency period? International Journal of Cancer 2002; 100(6): 723-728.
Terry PD, Miller AB, Rohan TE. Obesity and colorectal cancer risk in women. Gut 2002; 51; 191-194.
Terry PD. Miller AB, Rohan TE. A prospective study of cigarette smoking and the risk of endometrial cancer. British Journal of Cancer 2002; 86(9): 1430-1435.
Terry P, Jain M, Miller AB, Howe GR, Rohan TE. Dietary carotenoids and risk of breast cancer. The American Journal of Clinical Nutrition 2002; 76(4): 883-888.
Terry PD, Jain M, Miller AB, Howe GR, Rohan TE. Glycemic load, carbohydrate intake, and risk of colorectal cancer in women: a prospective cohort study. Journal of the National Cancer Institute 2003; 95(12): 914-916.