Tobacco use of Canadians, 2012 and 2013
Exposure to tobacco through smoking cigarettes or use of other tobacco products has been associated with a range of adverse health effects including several types of cancer (e.g. lung, stomach, liver, and oral cancers), coronary heart disease, and asthma.Note 1, Note 2 The most common routes of exposure to tobacco are by smoking cigarettes, using other tobacco products, or through second-hand smoke.Note 3 Cotinine is a by-product of the metabolism of nicotine (a chemical found in tobacco products) in the human body; the measured levels in urine reflect recent exposure to tobacco.Note 4
Results from the 2012 and 2013 Canadian Health Measures Survey (CHMS) indicate that average urine cotinine concentration of Canadians aged 12 to 79 was significantly higher among those who reported being daily or occasional smokers compared with those who reported being non-smokers. Smokers had an average cotinine concentration of 490 nanograms per millilitre (ng/mL) of cotinine in their urine (Chart 1). Among non-smokers aged 12 to 79, 89% had urine cotinine concentrations that were below the limit of detection (1.1 ng/mL) (data not shown).
Among smokers aged 12 to 79 year olds, 60 to 79 year olds had the highest urine cotinine concentration (940 ng/mL) and 12 to 39 year olds had the lowest (270 ng/mL) (Chart 1). Among smokers aged 40 to 59, males had a higher concentration of cotinine in their urine (840 ng/mL) compared with females (710 ng/mL) (Chart 1).
Prevalence of smoking based on urine cotinine concentration versus self-reported smoking status
Individuals with a urine cotinine concentration of greater than 50 ng/mL are classified as smokers.Note 5 Results indicate that 21% or about 1 in 5 Canadians aged 12 to 79 years were smokers based on their measured urine cotinine concentration (Chart 2). Smoking was more prevalent among males (25%) than females (17%) and among middle-aged adults 40 to 59 years (27%) than among the older and younger age groups (Chart 2).
Among Canadians who reported being a daily or occasional smoker, approximately 3% had measured urine cotinine levels less than or equal to 50 ng/mL (data not shown). On the other hand, 10% of self-reported non-smokers had a urine cotinine concentration greater than 50 ng/mL. The prevalence of Canadians who reported being a daily or occasional smoker was not significantly different from those with measured urine cotinine concentration above 50 ng/mL.
Exposure to second-hand smokeNote 7 among non-smokers
Among self-reported non-smokers, 21% indicated being exposed to second-hand smoke (data not shown). Canadians aged 12 to 19 had the highest prevalence of exposure to second-hand smoke (31%) compared with older and younger non-smokers. Approximately 13% of children aged 6 to 11 (who are assumed to be non-smokers), 25% of adults aged 20 to 39, 20% of adults aged 40 to 59, and 12% of older adults aged 60 to 79 reported being exposed to second-hand smoke (data not shown).
The majority of non-smokers (89%) had urine cotinine concentrations that were below detectable limits.Note 8 However, this differed significantly based on self-reported exposure to second-hand smoke. Among non-smokers who reported no recent exposure to second-hand smoke, 94% had urine cotinine concentrations that were below detectable limits (data not shown). In contrast, among non-smokers who reported recent exposure to second-hand smoke, 66% had urine cotinine concentrations below detectable limits.
About tobacco-related biomarkers
Nicotine is a naturally occurring chemical found in tobacco products. The metabolism of nicotine occurs in the liver and results in the production of several metabolites, including cotinine, which is known as the best biological marker of active or passive tobacco exposure.Note 1
Cotinine (measured as free cotinine) was measured in the urine of Canadians aged 3 to 79, and is presented in nanograms per millilitre (ng/mL). Concentrations are presented as a geometric mean, which is a type of average that is less influenced by extreme values than the traditional arithmetic mean. The geometric mean provides a better estimate of central tendency for highly skewed data. This type of data is common in the measurement of environmental chemicals in blood and urine.
Other tobacco-related chemicals were measured in urine as part of the CHMS (for respondents aged 12 to 79) including anabasine, cotinine-n-glucuronide, nicotine-n-glucuronide, hydroxycotinine and NNAL.
Additional information on cotinine and many other environmental substances are presented in Health Canada’s Third Report on Human Biomonitoring of Environmental Chemicals in Canada.
Additional information is available at Canadian Health Measures Survey.
For more information on the Canadian Health Measures Survey, please contact Statistics Canada's Statistical Information Service (toll-free 1-800-263-1136; 514-283-8300; firstname.lastname@example.org).
Health Canada. 2014. Nicotine and Its Major Metabolites as Biomarkers of Exposure to Tobacco. (accessed May 5, 2015).
Health Canada. 2014. NNALs: Measuring Exposure to a Tobacco-Specific Carcinogen. (accessed March 17, 2015).
Health Canada. 2014. Report on Human Biomonitoring of Environmental Chemicals in Canada. (accessed March 13, 2015).
National Biomonitoring Program. 2013. Biomonitoring Summary: Cotinine. U.S. Centers for Disease Control and Prevention, Atlanta, Georgia. (accessed April 13, 2015).
Society for Research on Nicotine and Tobacco Subcommittee on Biochemical Verification. 2002. “Biochemical verification of tobacco use and cessation.” Nicotine and Tobacco Research. Vol. 4, p. 149-159.
United States Department of Health and Human Services. 2014. The Health Consequences of Smoking: 50 Years of Progress. A report of the Surgeon General. Atlanta, GA. (accessed June 2, 2015).
Wong, S.L., Shields, M., Leatherdale, S., Malaison, E., and D. Hammond. 2012. “Assessment of validity of self-reported smoking status.” Health Reports. Vol. 23, no. 1. Statistics Canada Catalogue no. 82-003-XPE. Ottawa, Ontario (accessed April 13, 2015).
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